Microcystin-LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis

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• 作者：Benjamin L. Woolbright^a ; ^{bwoolbright@kumc.edu} ; C. David Williams^a ; Hongmin Ni^a ; Sean C. Kumer^b ; Timothy Schmitt^b ; Bartholomew Kane^b ; Hartmut Jaeschke^a
• 关键词：Microcystin ; Apoptosis ; Hepatocytes ; Transporters ; Necrosis ; Primary human hepatocytes
• 刊名：Toxicon
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：99-109
• 全文大小：3019 K
• 卷排序：125

文摘

Microcystin induced liver injury causes significant necrosis and hemorrhage in mice. Caspase inhibition fails to protect against microcystin induced liver injury in mice. There is limited caspase activation in human hepatocytes exposed to microcystin-LR. Caspase inhibitors do not protect against microcystin in human hepatocytes. Cell death via necrosis precedes cytoskeletal disruption.