文摘
This paper provides the first physiological evidence for the role of Zinc alpha2 glycoprotein (ZAG) in the regulation of lipid metabolism in hepatocytes. Our study has identified, for the first time, manipulation of ZAG expression in hepatocytes altered hepatic TG accumulation and the expression of key fatty acid oxidation genes and lipogenesis genes. ZAG could also dramatically stimulate adiponectin expression in hepatocytes.