刊名:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
出版年:2017
出版时间:January 2017
年:2017
卷:1864
期:1
页码:217-230
全文大小:2077 K
卷排序:1864
文摘
Tspan3 was identified as a novel ADAM10 interaction partner. Tspan3 modulates ectodomain shedding and intramembrane proteolysis of ADAM10. Tspan3 increases ADAM10-mediated generation of APP α-CTFs and reduces Aβ liberation. Tspan3 stabilizes ADAM10, APP and the γ-secretase complex at the plasma membrane Deficiency of Tspan3 is (most likely) compensated by other tetraspanins.