Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells
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- 作者：Tatiana Victonia ; b ; tatianavictoni@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Thomas Gicquela ; Aude Bodina ; Marion Daudea ; Hermann Tenorc ; Samuel Valenç ; ab ; e ; Philippe Devillierd ; Luis Cristovã ; o Portoe ; Vincent Lagentea ; Elisabeth Boichota
- 关键词：Neutrophil elastase ; COPD ; Roflumilast N-oxide ; Chemokine
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：1-8
- 全文大小：1077 K
文摘
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Neutrophil elastase increases chemokine production from A549 epithelial cells
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Neutrophil elastase induces the activation of p38α kinase, whereas it doesn't activate the JNK, ERK 1/2 and STAT3 pathways on A549 epithelial cells
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Roflumilast N-oxide, a PDE type 4 inhibitor, associated with prostaglandin E2, decreases chemokine production and p38 activation on the A549 epithelial cell stimulated by Neutrophil elastase.