Wnt signaling in atherosclerosis
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- 作者：W. Matthijs Blankesteijn ; wm.blankesteijn@maastrichtuniversity.nl" class="auth_mail" title="E-mail the corresponding author ; Kevin C.M. Hermans
- 关键词：ABCA1 ; ATP binding cassette transporter A1 ; APC ; adenomatous polyposis coli ; CAD ; coronary artery disease ; CAMKII ; calmodulin dependent protein kinase II ; CK1 ; casein kinase 1 ; COX ; cyclooxygenase ; CRD ; cysteine-rich domain ; DKK ; Dickkopf ; EC ; endothelial cell ; ELISA ; enzyme-linked immunosorbent assay ; GSK3尾 ; glycogen synthase kinase 3尾 ; IGFBP3 ; Insulin-Like Growth Factor Binding Protein 3 ; HUVEC ; human umbilical vein endothelial cells ; I魏B ; Inhibitor of nuclear factor kappa B ; IL ; Interleukin
- 刊名：European Journal of Pharmacology
- 出版年：2015
- 出版时间：15 September 2015
- 年：2015
- 卷：763
- 期：part_PA
- 页码：122-130
- 全文大小：594 K
文摘
Atherosclerosis is a disease of the vascular wall that forms the basis for a large spectrum of pathologies of various organs and tissues. Although massive research efforts in the last decades have yielded valuable information about its underlying molecular mechanisms, this has not led to a translation into effective therapeutic interventions that can stop the progression or even can induce regression of atherosclerosis. This underscores the importance of investigations on the involvement of novel signaling pathways in the development and progression of this condition. In this review we focus on the role of Wnt signaling in atherosclerosis. Experimental evidence is presented that Wnt signaling is involved in many aspects of the development and progression of vascular lesions including endothelial dysfunction, macrophage activation and the proliferation and migration of vascular smooth muscle cells. Subsequently, we will discuss the role of Wnt signaling in myocardial infarction and stroke, two common pathologies resulting from the progression of atherosclerotic lesions towards an unstable phenotype. Despite the fact that the published data sometimes are ambiguous or even conflicting, a picture is emerging that an attenuation of Wnt signaling is beneficial for the cardiovascular system that is compromised by atherosclerosis.