• 作者：Leyre M. Ló ; pez-Soria^a ; ^{leyremonica.lopezsoria@osakidetza.net} ; Elena Bereciartua^b ; Marta Santamarí ; a^c ; Luis Miguel Soria^a ; José ; Luis Hern&#225 ; ndez-Almaraz^a ; Alessandra Mularoni^b ; Javier Nieto^b ; Miguel Montejo^b
• 关键词：Candida nivariensis ; Fungemia ; Candidemia ; Caté ; ter ; Fluconazol ; Caspofungina
• 刊名：Revista Iberoamericana de Micolog¨ªa
• 出版年：2013
• 出版时间：3 January, 2013
• 年：2013
• 卷：30
• 期：1
• 页码：69-71
• 全文大小：149 K

Background

In recent years the incidence of candidemia caused by non-albicans Candida species has been increasing. Two cryptic species have been described within the Candida glabrata complex, Candida nivariensis and Candida bracarensis, which may be troublesome in laboratory identification and have lower susceptibility to fluconazole.

Aims

To describe the first isolation of C. nivariensis in the Iberian Peninsula from a patient suffering from a catheter-related fungemia.

Case report

An 81-year-old man was hospitalized for surgical treatment of an intestinal fistula that was associated to a severe malnutrition. Cultures of the patient's central venous catheter tip and blood yielded white colonies in BD CHROMagar Candida^? medium, which could not be identified by conventional microbiological methods. Although intravenous fluconazole was administered, blood cultures continued being positive 5 days later. The MIC values of the isolate were as follows: 1 ¦Ìg/ml for amphotericin B, 0.015 ¦Ìg/ml for anidulafungin, 0.125 ¦Ìg/ml for caspofungin, 0.015 ¦Ìg/ml for micafungin, 4 ¦Ìg/ml for fluconazole, 0.25 ¦Ìg/ml for itraconazole, 0.25 ¦Ìg/ml for posaconazole, and 0.03 ¦Ìg/ml for voriconazole. Antifungal treatment was changed to intravenous caspofungin for 2 weeks. The intestinal fistula was surgically treated. There was no evidence of relapse during the following month, and the patient was discharged. The isolate was identified as C. nivariensis based on DNA sequencing of the ITS regions of rRNA.

Conclusions

C. nivariensis should be regarded as an emerging pathogen which requires molecular methods for a definitive identification. Our patient was successfully treated with caspofungin.