Exploring correlation between bone metabolism markers and densitometric traits in extended families from Spain
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- 作者：Georgios Athanasiadisa ; athanasiadis@birc.au.dk" class="auth_mail" title="E-mail the corresponding author ; Laura Arranza ; Andrey Ziyatdinova ; Helena Brunela ; Mercedes Camachob ; Jorge Maloufc ; Nerea Hernandez-de Sosac ; Luis Vilab ; Jordi Casademontc ; Jose Manuel Soriaa
- 关键词：Osteoporosis ; Bone metabolism ; Densitometry ; Osteocalcin ; Leptin
- 刊名：Bone
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：1-6
- 全文大小：427 K
文摘
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The most important factors affecting circulating levels of bone metabolism markers are age and sex.
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Heritability for 12 bone metabolism markers was significant, ranging from 0.194 for plasma osteocalcin to 0.516 for plasma sclerostin levels.
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Genetic correlations between plasma osteocalcin and bone mineral density were strong with potentially useful diagnostic applications.
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Our findings provide useful insights for future gene mapping and genetic prediction studies.