Whether human herpes viruses contribute to morbidity and mortality after burns remains controversial. No direct evidence linked cytomegalovirus and herpes simplex virus infection with increased morbidity and mortality in burns. Cytomegalovirus reactivation is more common than a primary cytomegalovirus infection. Varicella zoster virus infections are rare after burns but have associated severe complications including lethality. The therapeutic effects of antiviral agents after burns warrant further investigation.