Activation of the phosphatidylinositol 3-kinase/Akt pathway by viral interferon regulatory factor 2 of Kaposi's sarcoma-associated herpesvirus
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- 作者：Yejin Kim1 ; Seho Cha1 ; Taegun Seo ; tseo@dongguk.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：KSHV ; vIRF2 ; PI3K/Akt pathway ; FOXO3A ; Caspase-3
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：470
- 期：3
- 页码：650-656
- 全文大小：1312 K
文摘
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vIRF2 inhibits FOXO3A-mediated transcriptional activity.
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FOXO3A translocates from the nucleus to cytoplasm in the presence of vIRF2.
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vIRF2 induces Akt phosphorylation at Thr308, but not Ser473.
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vIRF2 inhibits FOXO3A-mediated caspase-3 cleavage.
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Expression of vIRF2 promotes accumulation of ERK in the cytoplasm.