The Kaposi's-sarcoma-associated herpesvirus orf35 gene product is required for efficient lytic virus reactivation
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- 作者：Shir Bergson ; Inbal Itzhak ; Talya Wasserman ; Anastasia Gelgor ; Inna Kalt ; Ronit Sarid ; saridr@mail.biu.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kaposi's sarcoma-associated herpesvirus ; KSHV ; Open reading frame 35 (ORF35) ; BAC16 ; Reactivation ; Lytic infection
- 刊名：Virology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：499
- 期：Complete
- 页码：91-98
- 全文大小：806 K
文摘
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A recombinant viral clone that fails to express KSHV ORF35 (BAC16-ORF35-stop) was generated.
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BAC16-ORF35-stop preserves intact adjacent and overlapping reading frames.
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BAC16-ORF35-stop virus displayed significantly reduced lytic virus reactivation.
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Exogenous expression of ORF35-Flag reversed the effects of ORF35 deficiency.
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ORF35 is important for efficient lytic reactivation of KSHV.