The Itch ubiquitin ligase is required for KSHV RTA induced vFLIP degradation

详细信息    查看全文

• 作者：Jennifer C. Chmura^a ; ¹ ; Kevin Herold^a ; ¹ ; Ayana Ruffin^a ; Trudymae Atuobi^a ; Yetunde Fabiyi^a ; Ashley E. Mitchell^a ; Young Bong Choi^b ; Elana S. Ehrlich^a ; ¹ ; ^{eehrlich@towson.edu}
• 关键词：Kaposi's sarcoma ; KSHV ; HHV-8 ; Herpesvirus ; vFLIP ; RTA ; Ubiquitin ; Itch ; AIP4 ; NF-κB
• 刊名：Virology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：501
• 期：Complete
• 页码：119-126
• 全文大小：757 K
• 卷排序：501

文摘

The cellular ubiquitin ligase Itch is required for RTA induced vFLIP degradation. Itch interacts with RTA in both 293 T cells and naturally infected TREx BCBL1-RTA cells. Itch ubiquitinates vFLIP in vitro and in vivo. Mutant vFLIP that cannot interact with Itch is stable in the presence of RTA.