Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi’s sarcoma-associated herpesvirus infection
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文摘

Identify 2 novel peptide inhibitors that bind to the viral Bcl-2 homologue KsBcl-2.

Peptides stimulate cytochrome c release from mitochondria of KSHV-infected B cells.

Show KsBcl-2 as a viable target to kill latently KSHV-infected B cells.

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