- 作者：Nadia Jennifer Chiara Luca ; MD1 ; Irene Lara-Corrales ; MD ; MSc1 ; 2 ; Elena Pope ; MD ; MSc1 ; 2 ; elena.pope@sickkids.ca
- 关键词：AD ; Atopic dermatitis ; HSV ; Herpes simplex virus ; IV ; Intravenous
- 刊名：The Journal of Pediatrics
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：161
- 期：4
- 页码：671-675
- 全文大小：156 K
Objective
To describe the clinical characteristics of pediatric patients with eczema herpeticum and to determine the predictors of hospitalization, and recurrence and repeat episodes.Study design
A retrospective cohort study of patients 0-18 years of age diagnosed with eczema herpeticum between May 2000 and April 2009 was carried out at a tertiary pediatric care center in Canada. Seventy-nine patients were included. The primary outcome was hospitalization; secondary outcomes were recurrent and repeat episodes of eczema herpeticum.
Results
At presentation, 76 % of 79 patients with eczema herpeticum had a generalized eruption, 56 % had fever, 37 % had systemic symptoms, and 10 % had eye involvement (keratoconjunctivitis). Forty-five patients (57 % ) were hospitalized. Predictors for hospitalization included male sex (OR = 3.09; 95 % CI, 1.20-7.95, P = .017), fever (OR = 5.75; 95 % CI, 2.17-15.26, P < .001), systemic symptoms (OR = 2.84; 95 % CI, 1.06-7.62, P = .035), and age <1 year (OR = 7.17; 95 % CI, 2.17-23.72, P = .001). Recurrence rate (<1 month) was 8.9 % and rate of repeat episodes (>1 month) was 16 % . Hospitalized patients were more likely to have a repeat episode (OR = 8.25; 95 % CI, 0.99-68.69, P?= .05). Patients with a previous history of eczema herpeticum had increased likelihood of early recurrence (OR = 6.80; 95 % CI, 0.99-46.62, P = .05) and repeat episodes (OR = 9.43; 95 % CI, 1.52-55.9, P = .01).
Conclusions
Predictors of hospitalization in this cohort included male sex, age <1 year, fever, and systemic symptoms at presentation. Hospitalized patients may be at risk for repeat episodes of eczema herpeticum.