New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania
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- 作者：Paulino Delgado-Mé ; ndez ; Nora Herrera ; Haydee Chá ; vez ; Ana Esté ; vez-Braun ; Á ; ngel G. Ravelo ; Fern ; o Cortes ; Santiago Castanys ; Francisco Gamarro
- 关键词：Terpenoids ; Dihydro-β ; -agarofuran sesquiterpenes ; Lupanes ; Maytenus ; Celastraceae ; MDR ; Leishmania
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2008
- 出版时间：1 February 2008
- 年：2008
- 卷：16
- 期：3
- 页码：1425-1430
- 全文大小：149 K
文摘
Two new sesquiterpenes (1–2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.