Effect of surfactant and specific antibody on bacterial proliferation and lung function in experimental pneumococcal pneumonia

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• 作者：Xiaozhuang Gan ; Connie Jarstr ; Egbert Herting ; Per Berggren ; Bengt Robertson
• 刊名：International Journal of Infectious Diseases
• 出版年：2001
• 出版时间：2001
• 年：2001
• 卷：5
• 期：1
• 页码：9-18
• 全文大小：2072 K

文摘

Objective: To investigate the effect of surfactant and specific antibody on bacterial proliferation in experimental pneumococcal pneumonia.

Methods: Near-term newborn rabbits received a standard dose (107) of type 3 pneumococci via the airways. Control animals were sacrificed 1 minute later. Other animals were ventilated for 5 hours and treated via the tracheal cannula with surfactant (Curosurf 200 mg/kg), a mixture of surfactant and a polyclonal antipneumococcal antibody, the antibody without surfactant, or saline.

Results: There was a significant bacterial proliferation in lung tissue in all animals ventilated for 5 hours. Bacterial growth, expressed as log₁₀ colony forming units (CFU) per gram of lung tissue was less prominent in animals treated with a mixture of surfactant and specific antibody than in animals treated with antibody alone (median, 7.51, range, 6–7 vs. median, 7.92, range, 7.07–8.50; P < 0.05). Dynamic lung-thorax compliance was improved with surfactant or surfactant plus antibody in comparison with saline or antibody alone.

Conclusion: The data suggest that the suppressive effect of the antibody on bacterial proliferation becomes evident only when surfactant is administered together with the antibody.