Peripheral nerve exposure to HIV viral envelope protein gp120 induces neuropathic pain and spinal gliosis
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- 作者：Herzberg ; Uri ; et. al.
- 关键词：AIDS ; Chronic pain ; Neuropathy ; Microglia ; Astrocytes ; Spinal cord
- 刊名：Journal of Neuroimmunology
- 出版年：2001
- 出版时间：May 1, 2001
- 年：2001
- 卷：116
- 期：1
- 页码：29-39
- 全文大小：915 K
文摘
Painful sensory neuropathy is a common and debilitating consequence of human immunodeficiency virus (HIV). The underlying causes of neuropathic pain are most likely not due to direct infection of the nervous system by active virus. The goal of this study was to determine whether epineural exposure to the HIV-1 envelope protein gp120 could lead to chronic painful peripheral neuropathy. Two doses of gp120 or BSA control were transiently delivered epineurally via oxidized cellulose wrapped around the rat sciatic nerve. Animals were assessed for neuropathic pain behaviors at several intervals from 1–30 days following nerve surgery. Allodynia and hyperalgesia were observed within 1–3 days following gp120 and sustained throughout the testing period. The gp120-exposed sciatic nerve exhibited early but transient pathology, notably axonal swelling and increased tumor necrosis factor alpha (TNF-α) within the nerve trunk. In contrast, intense astrocytic and microglial activation was observed in the spinal cord, and this gliosis persisted for at least 30 days following epineural gp120, in parallel with neuropathic pain behaviors. These findings demonstrate that limited peripheral nerve exposure to HIV protein can induce persistent painful sensory neuropathy that may be sustained and magnified by long-term spinal neuropathology.