C-H activation reactions as useful tools for medicinal chemists

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• 作者：Eduardo J.E. Caro-Diaz ; Mariangela Urbano ; Daniel J. Buzard ; Robert M. Jones
• 关键词：C&ndash ; H activation ; Heterocycles ; Pharmaceuticals ; Drug discovery ; Medicinal chemistry
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：26
• 期：22
• 页码：5378-5383
• 全文大小：1960 K

文摘

In recent years, there has been an exponential rise in the number of reports describing synthetic methods that utilize catalytic sp³ and sp² C–H bond activation. Many have emerged as powerful synthetic tools for accessing biologically active motifs. Indeed, application to C–C and C–heteroatom bond formation, provides new directives for the construction of new pharmaceutical entities. Herein, we highlight some recent novel C–H activation processes that exemplify the utility of these transformations in medicinal chemistry.