Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

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• 作者：Jawaid Akhtar ; Ahsan Ahmed Khan ; Zulphikar Ali ; Rafi Haider ; M. Shahar Yar ; ^{msyar@rediffmail.com}
• 关键词：Anticancer ; Cytotoxic ; SARs ; N-Heterocycles
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：143-189
• 全文大小：16924 K
• 卷排序：125

文摘

The roles of various new N-heterocyclic moieties against different human cancer cell lines are discussed. The SAR of the newly synthesized derivative are illustrated in figures. Novel fused heterocyclic moieties and new complexes showing significant anticancer properties are also presented. Interactions of some newly synthesized compounds with the receptors is confirmed by docking studies.