Photochemical depolymerisation of dermatan sulfate and analysis of the generated oligosaccharides
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- 作者：Charalampos G. Panagosa ; b ; David P. Augusta ; Christine Jessonb ; Du&scaron ; an Uhrí ; na ; dusan.uhrin@ed.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：GAGs ; glycosaminoglycans ; LMWH ; low molecular weight heparin ; DS ; dermatan sulfate ; GalNAc ; N-acetylgalactosamine ; IdoA ; iduronic Acid ; HSQC ; heteronuclear single quantum coherence ; TOCSY ; total correlation spectroscopy ; HMBC ; heteronuclear multiple bond coherence
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：13-19
- 全文大小：1094 K
文摘
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Free radical photochemical depolymerisation generates GAG oligosaccharides.
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The structures of DS oligosaccharides were studied by NMR.
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Oligosaccharides with uronic acid as the reducing end monosaccharides were found.
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Acetylgalactosaminic reducing end monosaccharides were also generated.
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No desulfation of the generated oligosaccharides was found.