Antioxidants and α-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships
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- 作者：Lu Zhanga ; Zong-cai Tua ; b ; tuzc_mail@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Tao Yuanc ; Hui Wangb ; Xing Xieb ; Zhi-feng Fub
- 关键词：HPLC ; high performance liquid chromatography ; Semi-HPLC ; semi-preparative high performance liquid chromatography ; MPLC ; medium pressure liquid chromatography ; 1D NMR ; one-dimensional nuclear magnetic resonance spectroscopy ; 2D NMR ; two-dimensional nuclear magnetic resonance spectroscopy ; COSY ; 1H&ndash ; 1H correlation spectroscopy ; HSQC ; heteronuclear single-quantum correlation spectroscopy ; HMBC ; heteronuclear multiple-bond correlation spectroscopy ; IC50 ; half maximal inhibitory concentration ; S
- 刊名：Food Chemistry
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：208
- 期：Complete
- 页码：61-67
- 全文大小：476 K
文摘
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Bioactivity-guided approach is a valuable tool for isolating active compounds.
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Phenethyl cinnamides and 3,4,5-triCQA show the best α-glucosidase inhibition.
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3,4,5-TriCQA and diCQAs are the predominant antioxidants.
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Caffeoylation of quinic acid and methoxylation of flavonol improve the antioxidant activity.
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Methylation and cis structure weak the α-glucosidase inhibition of phenethyl cinnamides.