Toxin-induced pore formation is hindered by intermolecular hydrogen bonding in sphingomyelin bilayers
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- 作者：Sara Garcí ; a-Linaresa ; b ; Juan Palacios-Ortegaa ; b ; Tomokazu Yasudab ; c ; Mia Å ; strandb ; José ; G. Gavilanesa ; Á ; lvaro Martí ; nez-del-Pozoa ; J. Peter Slotteb ; jpslotte@abo.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：BA ; benzyl alcohol ; DPH ; diphenyl hexatriene ; EqtII ; equinatoxin II ; LUV ; large unilamellar vesicle ; FraC ; fragaceatoxin C ; OSM ; N-oleoyl-d-erythro-sphingomyelin ; POPC ; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine ; PSM ; N-palmitoyl-d-erythro-sphingomyelin ; SM ; sphingomyelin ; StnI ; sticholysin I ; StnII ; sticholysin II
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1858
- 期：6
- 页码：1189-1195
- 全文大小：742 K
文摘
- 5">
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5">Sphingomyelin and dihydro sphingomyelin hydrogen bond differently.
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Sticholysin binds to sphingomyelin and forms pores in fluid bilayers.
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5">Sticholysin failed to form pores in fluid dihydro sphingomyelin bilayers.
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Strong intermolecular hydrogen bonding appeared to hinder pore formation.