The role of connexin43-Src interaction in astrocytomas: A molecular puzzle
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- 作者：A. Tabernero ; ataber@usal.es" class="auth_mail" title="E-mail the corresponding author ; E. Gangoso&dagger ; ; M. Jaraí ; z-Rodrí ; guez ; J.M. Medina
- 关键词：Cx43 ; connexin43 ; Cx43CT ; C-terminal domain of connexin43 ; GLUT-3 ; glucose transporter-3 ; GSC ; glioma stem cells ; HIF ; hypoxia-inducible factor ; HK2 ; type II hexokinase ; IDP ; intrinsically disordered protein ; IDR ; intrinsically disordered region ; MAPK ; mitogen-activated protein kinases ; miRNA ; microRNA ; MTOC ; microtubule organizing center ; PDZ ; postsynaptic density 95/disk-large/zona occludens ; pRb ; retinoblastoma protein ; PTEN ; phosphatidylinositol 3 ; 4 ; 5-trisphosphate 3-phosphatase and dual-spe
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：26 May 2016
- 年：2016
- 卷：323
- 期：Complete
- 页码：183-194
- 全文大小：1117 K
文摘
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Cx43 protein but not mRNA is downregulated in high-grade astrocytomas.
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The interaction of Cx43 with Src modifies the binding to important proteins, such as ZO-1 and tubulin.
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The inhibition of Src promoted by Cx43 reduces cell cycle, glucose uptake and stem cell phenotype.
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20">The sequence of Cx43 that interacts with Src could be a source of inspiration for new glioma therapies.