HIF-1α and PPARγ during physiological cardiac hypertrophy induced by pregnancy: Transcriptional activities and effects on target genes
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- 作者：José ; G. Soñ ; anez-Organisa ; jorganis@navojoa.uson.mx" class="auth_mail" title="E-mail the corresponding author ; josegpeso@gmail.com" class="auth_mail" title="E-mail the corresponding author ; José ; A. Godoy-Lugoa ; Magally L.E. Herná ; ndez-Palomaresa ; Daniel Rodrí ; guez-Martí ; neza ; Jesú ; s A. Rosas-Rodrí ; gueza ; Guadalupe Gonzá ; lez-Ochoaa ; Adolfo Virgen-Ortizb ; Rudy M. Ortizc
- 关键词：HIF-1α ; hypoxia inducible factor 1-α ; PPARγ ; peroxisome proliferator-activated receptor γ ; FFA ; free fatty acid ; TAG ; triacylglycerol ; G3PD1 ; glyceraldehyde-3-phosphate dehydrogenase-1 ; GPAT ; glycerol phosphate acyltransferase ; DHAP ; dihydroxyacetone phosphate ; G3P ; glycerol-3-phosphate ; GLUT4 ; glucose transporter type 4 ; HK2 ; hexokinase type 2 ; PFK-M ; phosphofructokinase type M ; GAPDH ; glyceraldehyde 3 phosphate dehydrogenase ; ACoAS ; acyl CoA synthase ; CPT ; carnitine palmitoyl transferase ; ISCD
- 刊名：Gene
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：591
- 期：2
- 页码：376-381
- 全文大小：587 K
文摘
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HIF-1α and PPARγ are activate during physiologic cardiac hypertrophy induced by pregnancy
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The physiologic cardiac hypertrophy induced by pregnancy up-regulate glycolytic and glycerol-lipid biosynthesis genes
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Cardiac glucose and lactate levels increase during pregnancy and postpartum.
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20">The pregnancy-induced HIF-1α and PPARγ activation is reversible during their reversible process postpartum.