The lncRNA MALAT1, acting through HIF-1α stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells
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- 作者：Fei Luoa ; b ; 1 ; Xinlu Liua ; b ; 1 ; Min Lingc ; 1 ; Lu Lua ; b ; Le Shia ; b ; Xiaolin Lua ; b ; Jun Lid ; Aihua Zhangd ; Qizhan Liua ; b ; drqzliu@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：lncRNAs ; long non-coding RNAs ; MALAT1 ; metastasis-associated lung adenocarcinoma transcript 1 ; HIFs ; hypoxia inducible factors ; VHL ; Von Hippel&ndash ; Lindau ; Glut-4 ; glucose transporter type 4 ; Eno-1 ; enolase-1 ; HK-2 ; hexokinase-2 ; PDK-1 ; pyruvate dehydrogenase kinase-1 ; LDH ; lactate dehydrogenase ; G6PD ; glucose-6-phosphate dehydrogenase
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1685-1695
- 全文大小：2000 K
文摘
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In human hepatic epithelial (L-02) cells, arsenite induces glycolysis.
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In L-02 cells, HIF-1α, not HIF-2α, is involved in arsenite-induced glycolysis.
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Arsenite up-regulates the lncRNA, MALAT1, which increases HIF-1α expression through blocking the ubiquitin-proteasome pathway.
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20">In L-02 cells, MALAT1 regulation of HIF-1α is involved arsenite-induced glycolysis.