Solvent Removal Induces a Reversible β-to-α Switch in Oligomeric Aβ Peptide
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- 作者：Senthil T. Kumar1 ; &dagger ; ; Jö ; rg Leppert2 ; Peter Bellstedt2 ; &Dagger ; ; Christoph Wiedemann2 ; § ; ; Marcus Fä ; ndrich1 ; ; Matthias Gö ; rlach2 ;
- 关键词：ATR-FTIR ; attenuated total reflectance Fourier-transform infrared ; ssNMR ; solid-state NMR ; HFIP ; 1 ; 1 ; 1 ; 3 ; 3 ; 3-hexafluoro isopropanol ; TEM ; transmission electron microscopy ; TFA ; trifluoroacetate
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：29 January 2016
- 年：2016
- 卷：428
- 期：2
- 页码：268-273
- 全文大小：611 K
文摘
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Aβ oligomers are linked to Alzheimer's disease.
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Solvent removal switches conformation of oligomeric Aβ peptide from β to α.
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This β-to-α structural switch is reversible upon resolvation.
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The structural transition differs from irreversible protein aggregation upon lyophilization.
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The β-to-α switch may operate during Aβ's interactions with cellular membrane lipids.