Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α

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• 作者：Yaarit Adamovich¹ ; ³ ; Benjamin Ladeuix¹ ; ³ ; Marina Golik¹ ; Maarten P. Koeners² ; Gad Asher¹ ; ⁴ ; ^{gad.asher@weizmann.ac.il}
• 关键词：circadian rhythms ; clock ; oxygen ; HIF1 ; jetlag ; metabolism ; entrainment ; Cry2 ; Rorα
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：93-101
• 全文大小：10029 K
• 卷排序：25

文摘

O2 levels exhibit daily rhythms in blood and tissue of rodents Physiological O2 rhythms reset clocks in cultured cells in HIF1α-dependent manner Several core clock genes respond to changes in O2 levels in HIF1α-dependent fashion Modulation of O2 levels accelerates the recovery of mice in a jet lag protocol