A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis

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• 作者：Kohki Fujikawa ; Tomohiro Nohara ; Akihiro Imamura ; Hiromune Ando ; Hideharu Ishida ; Makoto Kiso
• 关键词：Ganglioside ; Intramolecular glycosylation ; Glucosyl ceramide ; Sialic acid
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：17 February 2010
• 年：2010
• 卷：51
• 期：7
• 页码：1126-1130
• 全文大小：631 K

文摘

A cyclic glucosyl ceramide (GlcCer) acceptor has been developed as a versatile building block for the synthesis of complex ganglioside. A macrocyclic GlcCer acceptor, which was the product of intramolecular glycosylation between glucose and ceramide, exhibited high reactivity during the coupling reactions with a variety of complex oligosaccharyl donors, thereby furnishing the corresponding ganglioside frameworks in high yields.