cGMP as second messenger during Dictyostelium chemotaxis
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- 作者：van Haastert ; Peter J.M. ; Kuwayama ; Hidekazu
- 关键词：Signal transduction ; Osmotic stress ; Guanylyl cyclase ; Adaptation ; Genetics
- 刊名：FEBS Letters
- 出版年：1997
- 出版时间：June 23, 1997
- 年：1997
- 卷：410
- 期：1
- 页码：25-28
- 全文大小：399 K
文摘
The chemoattractant cAMP induces directed cell locomotion in Dictyostelium cells. Several second messenger pathways are activated upon binding of cAMP to G-protein-coupled receptors, including adenylyl cyclase, guanylyl cyclase, phospholipase C, and the opening of plasma membrane Ca2+ channels. These second messenger responses are unaltered in many chemotactic mutants, except for the cGMP response. Activation of guanylyl cyclase depends on G-proteins and is regulated by a cGMP-binding protein in a complex manner. This cGMP-binding protein also mediates intracellular functions of cGMP to activate a PKC-related kinase that phosphorylates myosin II heavy chain, thereby allowing myosin filaments to rearrange during cell movement.