Regulatory mechanisms of Hertwig壮s epithelial root sheath formation and anomaly correlated with root length

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• 作者：Mika Kumakami-Sakano ; Keishi Otsu ; Naoki Fujiwara ; Hidemitsu Harada ; ^{hideha@iwate-med.ac.jp" class="auth_mail}
• 关键词：Hertwig壮s epithelial root sheath ; Tooth development ; Root formation ; Short root anomaly
• 刊名：Experimental Cell Research
• 出版年：15 July 2014
• 年：2014
• 卷：325
• 期：2
• 页码：78-82
• 全文大小：993 K

文摘

Teeth are composed of two domains, the enamel-covered crown and cementum-covered root. The mechanism for determining the transition from crown to root is important for understanding root anomaly diseases. Hertwig壮s epithelial root sheath (HERS) is derived from the dental epithelium and is known to drive the growth of root dentin and periodontal tissue. Some clinical cases of hypoplastic tooth root are caused by the cessation of HERS development. Understanding the mechanisms of HERS development will contribute to the study of the disease and dental regenerative medicine. However, the developmental biology of tooth root formation has not been fully studied, particularly regarding HERS formation. Here, we describe the mechanisms of HERS formation on the basis of analysis of cell dynamics using imaging and summarize how the growth factor and its receptor regulate cell behavior of the dental epithelium.