The subjects were 1153 Japanese quartet families. Their HLA-A, -B, and -DRB1 alleles were typed by SSO method. Each family has a father, a mother, and a sibling of the patient requiring hematopoietic stem cell transplantation. The parents were divided into two groups: (i) 5–6/6 antigen matched parents (n = 143), and (ii) 0–4/6 antigen matched parents (n = 2163). In each group, NIAH (non-inherited paternal or maternal antigen haplotype) were counted and these frequencies were calculated.
Top eight NIAH frequencies of all parents, group (i), and group (ii) are shown below.
There were not many tendencies for NIAH of 5-6/6 antigen matched parents to be biased against frequent haplotypes in the Japanese population.