Relation between interleukin-6 level and subclinical intracranial large-artery atherosclerosis

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• 作者：Taku Hoshi ; Kazuo Kitagawa ; Hiroshi Yamagami ; Shigetaka Furukado ; Hidetaka Hougaku ; Masatsugu Hori
• 关键词：Intracranial large-artery atherosclerosis ; Inflammation ; Interleukin-6 ; Magnetic resonance angiography
• 刊名：Atherosclerosis
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：197
• 期：1
• 页码：326-332
• 全文大小：132 K

文摘

The levels of systemic inflammatory markers have been shown to predict future cardiovascular events, but whether they are associated with intracranial large-artery atherosclerosis is uncertain. We investigated the relation between the level of inflammatory markers interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) and subclinical intracranial large-artery atherosclerosis in patients with risk factors for atherosclerosis.

Methods

Magnetic resonance angiography (MRA) was performed in 226 Japanese patients age range, 45–87 years without a history of cerebrovascular disease. Serum IL-6 and hsCRP and conventional risk factors for atherosclerosis were assessed.

Results

Forty-six patients (20.4 % ) were found by MRA to have one or more intracranial steno-occlusive lesions. Mean IL-6 levels were higher in patients with intracranial large-artery atherosclerosis than in those without. In addition, patients in the highest IL-6 tertile had higher unadjusted odds ratio (OR) for intracranial large-artery atherosclerosis than that of those in the lowest tertile (OR 3.25, 95 % CI; 1.42–7.39). These associations were only slightly attenuated upon adjustment for conventional atherosclerotic risk factors and carotid intima-media thickness.

Conclusions

Increased levels of IL-6 appear to be associated with intracranial large-artery disease, suggesting a role for the inflammatory process in atherosclerosis of intracranial large arteries.