Estrogen induces stromal cell-derived factor 1 (SDF-1/CXCL12) production in human endometrial stromal cells: a possible role of endometrial epithelial cell growth

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• 作者：Akihiro Tsutsumi ; Hidetaka Okada ; Tsuyoshi Nakamoto ; Rika Okamoto ; Katsuhiko Yasuda ; Hideharu Kanzaki
• 关键词：SDF-1 (CXCL12) ; CXCR4 ; estrogen ; endometrial stromal cells ; human endometrium
• 刊名：Fertility and Sterility
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：95
• 期：1
• 页码：444-447
• 全文大小：238 K

文摘

Estradiol enhanced stromal cell-derived factor 1 (SDF-1/CXCL12) production levels in human endometrial stromal cells (ESCs) in a time- and dose-dependent manner that could be completely abolished by ICI 182,780 (estrogen receptor antagonist) and medroxyprogesterone acetate. Although SDF-1 was undetectable in the Ishikawa human endometrial epithelial cell line, its receptor (CXCR4) messenger RNA levels in Ishikawa cells were much higher than those in ESCs, and furthermore SDF-1 induced the proliferation of Ishikawa cells; SDF-1 secreted from ESCs may play a role in endometrial epithelial cell growth in the paracrine system.