- 作者：Nobuyoshi Fukumitsu ; Shinji Sugahara ; Hidetsugu Nakayama ; Kuniaki Fukuda ; Masashi Mizumoto ; Masato Abei ; Junichi Shoda ; Eriko Thono ; Koji Tsuboi ; Koichi Tokuuye
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2009
- 出版时间：1 July 2009
- 年：2009
- 卷：74
- 期：3
- 页码：831-836
- 全文大小：178 K
Purpose
To evaluate the efficacy and safety of hypofractionated proton beam therapy for patients with hepatocellular carcinoma (HCC).Methods and Materials
Between September 2001 and August 2004, 51 patients with HCC greater than 2 cm away from the porta hepatis or gastrointestinal tract were treated with proton beam therapy to 66 Gy-equivalents (GyE) in 10 fractions.
Results
Overall survival rates were 49.2 and 38.7 % at 3 and 5 years after treatment. Local control rates were 94.5 and 87.8 % at 3 and 5 years after treatment. Posttreatment serum α-fetoprotein values were significantly reduced when compared with pretreatment values (p < 0.0001). Patients experienced only minor acute reactions of Grade 1 or less, and 3 patients experienced late sequelae of Grade 2 or higher. However, there were no treatment-related deaths.
Conclusions
Hypofractionated proton beam therapy is safe and well-tolerated by patients with HCC located greater than 2 cm away from the porta hepatis or gastrointestinal tract and may be effective alternative to other modalities.