- 作者：Yoshiko Oshiro ; Shinji Sugahara ; Mio Noma ; Masato Sato ; Yuzuru Sakakibara ; Takeji Sakae ; Yasutaka Hayashi ; Hidetsugu Nakayama ; Koji Tsuboi ; Nobuyoshi Fukumitsu ; Ayae Kanemoto ; Takayuki Hashimoto ; Koic
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2008
- 出版时间：1 November 2008
- 年：2008
- 卷：72
- 期：3
- 页码：723-727
- 全文大小：445 K
Purpose
To investigate the effect of proton beam therapy (PBT) on implanted cardiac pacemaker function.Methods and Materials
After a phantom study confirmed the safety of PBT in patients with cardiac pacemakers, we treated 8 patients with implanted pacemakers using PBT to a total tumor dose of 33–77 gray equivalents (GyE) in dose fractions of 2.2–6.6 GyE. The combined total number of PBT sessions was 127. Although all pulse generators remained outside the treatment field, 4 patients had pacing leads in the radiation field. All patients were monitored by means of electrocardiogram during treatment, and pacemakers were routinely examined before and after PBT.
Results
The phantom study showed no effect of neutron scatter on pacemaker generators. In the study, changes in heart rate occurred three times (2.4 % ) in 2 patients. However, these patients remained completely asymptomatic throughout the PBT course.
Conclusions
PBT can result in pacemaker malfunctions that manifest as changes in pulse rate and pulse patterns. Therefore, patients with cardiac pacemakers should be monitored by means of electrocardiogram during PBT.