- 作者：Hidetsugu Nakayama ; Shinji Sugahara ; Mari Tokita ; Hiroaki Satoh ; Koji Tsuboi ; Shigemi Ishikawa ; Koichi Tokuuye
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2010
- 出版时间：1 October 2010
- 年：2010
- 卷：78
- 期：2
- 页码：467-471
- 全文大小：123 K
Purpose
To evaluate in a retrospective review the role of proton beam therapy for patients with medically inoperable Stage I non–small-cell lung cancer (NSCLC).Patients and Methods
From November 2001 to July 2008, 55 medically inoperable patients with Stage I NSCLC were treated with proton beam therapy. A total of 58 (T1/T2, 30/28) tumors were treated. The median age of study participants was 77 years (range, 52–86 years). A total dose of 66 GyE in 10 fractions was given to peripherally located tumors and 72.6 GyE in 22 fractions to centrally located tumors.
Results
The rates (95 % confidence interval) of overall and progression-free survival of all patients and of local control of all tumors at 2 years were 97.8 % (93.6–102.0 % ), 88.7 % (77.9–99.5 % ), and 97.0 % (91.1–102.8 % ), respectively. There was no statistically significant difference in progression-free rate between T1 and T2 tumors (p = 0.87). Two patients (3.6 % ) had deterioration in pulmonary function, and 2 patients (3.6 % ) had Grade 3 pneumonitis.
Conclusion
Proton beam therapy was effective and well tolerated in medically inoperable patients with Stage I NSCLC.