- 作者：Naoto Kanesaka ; M.D. ; Ph.D.&lowast ; ; kaneka@tokyo-med.ac.jp ; Ryuji Mikami ; M.D.&lowast ; ; Hidetsugu Nakayama ; M.D.&lowast ; ; Sachika Nogi ; M.D.&lowast ; ; Yu Tajima ; M.D.&lowast ; ; Nobuyuki Nakajima ; M.D.&dagger ; ; Jun Wada ; M.D.&dagger ; ; Tamotsu Miki ; M.D.&dagger ; ; Jou Haraoka ; M.D.&dagger ; ; Mitsuru Okubo ; M.D.&Dagger ; ; Shinji Sugahara ; M.D.§ ; ; Koichi Tokuuye ; M.D.&lowast ;
- 关键词：Craniopharyngioma ; Stereotactic radiotherapy ; Visual field
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 出版时间：15 March, 2012
- 年：2012
- 卷：82
- 期：4
- 页码：1356-1360
- 全文大小：354 K
Purpose
To retrospectively evaluate the effectiveness of fractionated stereotactic radiotherapy (FSRT) for craniopharyngioma.Methods and Materials
Between 1999 and 2005, 16 patients with craniopharyngioma were referred to Tokyo Medical University Hospital. They received FSRT alone after histologic confirmation by needle biopsy and underwent cyst drainage via endoscopy. The median prescription dose fraction was 30 Gy in six fractions. All patients except 1 were followed up until December 2009 or death.
Results
The median follow-up period was 52 months (range, 4-117 months). Of the 17 patients, 3 experienced recurrence 4 to 71 months after FSRT. The 3-year local control rate was 82.4 % . One patient died of thyroid cancer, and the 3-year survival rate was 94.1 % . Eight patients had improved visual fields at a median of 2.5 months after FSRT, but hormonal functions did not improve in any patient.
Conclusions
FSRT after cyst drainage seems to be safe and effective for patients with craniopharyngiomas, and it may be a safe alternative to surgery.