Novel in vivo imaging analysis of an inner ear drug delivery system: Drug availability in inner ear following different dose of systemic drug injections
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- 作者：Sho Kanzakia ; 1 ; skan@a7.keio.jp" class="auth_mail" title="E-mail the corresponding author ; Kotaro Watanabea ; 1 ; Masato Fujiokaa ; Shinsuke Shibatab ; Masaya Nakamurac ; Hirotaka James Okanob ; d ; Hideyuki Okanob ; Kaoru Ogawaa
- 关键词：Drug delivery system ; Inner ear ; Bioluminescence imaging ; Mouse
- 刊名：Hearing Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：330
- 期：part_PA
- 页码：142-146
- 全文大小：995 K
文摘
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Luciferin injected systemically appeared in the inner ear in different volume of drug.
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Drug volume is an important parameter to know if the inner ear requires a higher level of the drug.
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We observed that it is the volume of a drug—not its concentration—that is the important factor.
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Indeed, the volume of a drug injected systemically correlated with the concentration of that drug in the inner ear.