Specific stabilization of CFTR by phosphatidylserine

详细信息    查看全文

• 作者：Ellen Hildebrandt^a ; ^{ellen.hildebrandt@ttuhsc.edu} ; Netaly Khazanov^b ; ^{netalyk@gmail.com} ; John C. Kappes^c ; ^d ; ^{kappesjc@uab.edu} ; Qun Dai^c ; ^daiq@uab.edu ; Hanoch Senderowitz^b ; ^{hanoch@biu.ac.il} ; ^{hsenderowitz@gmail.com} ; Ina L. Urbatsch^a ; ^{ina.urbatsch@ttuhsc.edu}
• 关键词：CF ; cystic fibrosis ; CFTR ; cystic fibrosis transmembrane conductance regulator ; EGFP ; enhanced green fluorescent protein ; NBD ; nucleotide binding domain ; PI ; phosphatidylinositol ; POPC ; 1-palmitoyl-2-oleoyl-phosphatidylcholine ; POPE ; 1-palmitoyl-2-oleoyl-phosphatidylethanolamine ; POPG ; 1-palmitoyl-2-oleoyl-phosphatidylglycerol ; POPS ; 1-palmitoyl-2-oleoyl-phosphatidylserine ; RI ; regulatory insertion ; 2PT ; S492P/A534P/I539T
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1859
• 期：2
• 页码：289-293
• 全文大小：481 K
• 卷排序：1859

文摘

Phosphatidylserine specifically stabilizes ATPase activity of purified human CFTR Select mutations together with phosphatidylserine further enhance thermal stability With PS, turnover for ATP hydrolysis by CFTR is comparable to other ABC transporters