Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes

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• 作者：Himanshu Atheaya ; Shabana I. Khan ; Ritu Mamgain ; Diwan S. Rawat
• 关键词：Tetraoxane ; Antimalarial activity ; Cytotoxicity ; Differential scanning calorimetry
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2008
• 出版时间：15 February 2008
• 年：2008
• 卷：18
• 期：4
• 页码：1446-1449
• 全文大小：169 K

文摘

Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H₂O₂/TFE in presence of MeReO₃ as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry.