Investigations of the synergistic enhancement of antimicrobial activity in mixtures of magainin 2 and PGLa
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- 作者：Elise Glattard1 ; Evgeniy S. Salnikov1 ; Christopher Aisenbrey ; Burkhard Bechinger ; bechinger@unistra.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CI ; combination index ; di-C10 ; 0-PC ; 1 ; 2-didecanoyl-sn-glycero-3-phosphocholine ; DMPC ; 1 ; 2-dimyristoyl-sn-glycero-3-phosphocholine ; DMPG ; 1 ; 2-dimyristoyl-sn-glycero-3-phospho-(1&prime ; -rac-glycerol) ; ITC ; isothermal titration calorimetry ; MICn ; minimal concentration to inhibit n% of bacterial growth ; MH ; Mueller Hinton ; NBD ; 4-fluoro-7-nitrobenz-2-oxa-1 ; 3-diazole ; NMR ; nuclear magnetic resonance ; OD ; optical density ; PC ; phosphatidylcholine ; PE ; phosphatidylethanolamine ; PG ; phosphatidylglycerol
- 刊名：Biophysical Chemistry
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：210
- 期：Complete
- 页码：35-44
- 全文大小：1051 K
文摘
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PGLa orients parallel to the surface of membranes made from E. coli lipids in the absence or presence of magainin 2.
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Magainin strongly disorders the phospholipid head groups of E. coli lipids.
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Synergism does not require pronounced direct/covalent peptide–peptide interactions.
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Lack of correlation between the tendency of PGLa variants to span thin membranes and their synergistic activity