New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

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• 作者：Anas Allam^a ; ¹ ; Laure Maigre^b ; ¹ ; Rodolphe Alves de Sousa^a ; Estelle Dumont^b ; Julia Vergalli^b ; Jean-Marie Pagè ; s^b ; ^{jean-marie.pages@univ-amu.fr} ; Isabelle Artaud^a ; ^{isabelle.artaud@parisdescartes.fr}
• 关键词：Antibacterial activity ; Gram-negative bacteria ; Metal-binding groups ; Membrane permeability ; Multidrug resistant bacteria ; Neamine derivatives
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：748-756
• 全文大小：1230 K
• 卷排序：127

文摘

Synthesis of new amphiphilic neamine conjugates bearing a metal binding motif. Evaluation of their specific metal binding ability in the Mueller Hinton medium. Significant antibacterial activity against a multiresistant clinical isolate compared to usual antibiotic. Membranotropic action: permeabilization of the outer membrane and action on the efflux transporter in the inner membrane.