Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
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- 作者：Sebum Lee1 ; Yulei Shang1 ; Stephanie A. Redmond2 ; 3 ; Anatoly Urisman1 ; Amy A. Tang1 ; Kathy H. Li4 ; Alma L. Burlingame4 ; Ryan A. Pak1 ; Ana Jovičić5 ; Aaron D. Gitler5 ; Jinhua Wang6 ; Nathanael S. Gray6 ; William W. Seeley1 ; 2 ; Teepu Siddique7 ; Eileen H. Bigio8 ; Virginia M.-Y. Lee9 ; John Q. Trojanowski9 ; Jonah R. Chan2 ; 3 ; Eric J. Huang1 ; 2 ; 3 ; 10 ; eric.huang2@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：91
- 期：1
- 页码：41-55
- 全文大小：6078 K
文摘
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ER stress activates epitope-specific phosphorylation of HIPK2 to promote cell death
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Loss of HIPK2 mitigates neurodegeneration and improves survival in SOD1G93A mice
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TDP-43 proteinopathy positively correlates with HIPK2-JNK activation in ALS
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HIPK2 inhibitors protect neurons from toxicity by SOD1G93A and TDP-43 proteinopathy