Increased anxiety-like behaviors, but blunted cortisol stress response after neonatal hippocampal lesions in monkeys

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• 作者：Jessica Raper^a ; ^b ; ^{jraper@emory.edu} ; Mark Wilson^b ; ^c ; Mar Sanchez^b ; ^c ; Christa Payne^b ; ^d ; Jocelyne Bachevalier^a ; ^b
• 关键词：Emotion ; Development ; HPA-axis ; Diurnal rhythm ; Macaque
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：57-66
• 全文大小：1309 K
• 卷排序：76

文摘

Early hippocampal lesions cause increased anxiety-like and self-directed behaviors. Despite increased anxiety-like behaviors, monkey had a blunted cortisol stress response. Data is similar to adult-onset hippocampal damage in humans and monkeys. Implication for mood and psychiatric disorders with altered hippocampal development.