HIF-1α-mediated upregulation of SERCA2b: The endogenous mechanism for alleviating the ischemia-induced intracellular Ca2+ store dysfunction in CA1 and CA3 hippocampal neurons
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- 作者：Olga Kopacha ; 1 ; Anastasiia Maistrenkob ; Iryna Lushnikovab ; Pavel Belanc ; d ; Galina Skibob ; Nana Voitenkoa ; d ; nana@biph.kiev.ua" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prolonged ischemic conditions ; Intracellular free Ca2+ concentration ([Ca2+]i) ; HIF-1α ; Ca2+-ATPase ; SERCA2b ; CA1 and CA3 hippocampal neurons
- 刊名：Cell Calcium
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：59
- 期：5
- 页码：251-261
- 全文大小：1570 K
文摘
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OGD impairs intracellular Ca2+ regulation and Ca2+ store function in CA1 neurons.
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Ischemic impairments were accompanied by downregulated PMCA1 and PMCA2 mRNAs.
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In CA3 neurons, OGD increased SERCA2b mRNA with no effects on Ca2+ regulation.
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Stabilization of HIF-1α upregulated the SERCA2b mRNA in CA1 neurons.
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HIF-1α stabilization improved Ca2+ regulation and Ca2+ stores in CA1 neurons post-OGD.