TRH modulates glutamatergic synaptic inputs on CA1 neurons of the mouse hippocampus in a biphasic manner
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- 作者：Hadi Zarif ; Agnè ; s Petit-Paitel ; Catherine Heurteaux ; Joë ; lle Chabry ; Alice Guyon ; alice.guyon@ipmc.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thyrotropin-Releasing Hormone (TRH) ; Hippocampus ; Mice ; Glutamatergic transmission ; NMDA receptors ; AMPA/kainate receptors ; Long-Term Potentiation (LTP)
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：69-81
- 全文大小：1810 K
文摘
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In acute mouse hippocampal slices, TRH modulates the excitatory transmission in CA1 pyramidal neurons in a complex way.
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TRH displays a biphasic effect on glutamatergic CA3-CA1 transmission, first a depression followed by a potentiation.
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Depression of excitatory CA3-CA1 transmission is prevented by the NMDA receptor antagonist DL-APV.
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TRH blocks the induction of LTP by a high frequency stimulation of the Shaffer's collaterals.
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Potentiation of the CA3-CA1 transmission is accelerated by NMDA receptor antagonism and modulated by GABA antagonists.