Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting 蓻 germline transcription induced by STAT6 activation

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• 作者：Yoon Hee Kim ; Miki Yoshimoto ; Kazuko Nakayama ; Sousuke Tanino ; Yoshinori Fujimura ; Koji Yamada ; Hirofumi Tachibana
• 关键词：蓻 Germline transcript ; IgE ; Pentagalloylglucose ; Signal transducers and activators of transcription6 ; Tannic acid
• 刊名：FEBS Open Bio
• 出版年：2013
• 年：2013
• 卷：3
• 期：Complete
• 页码：341-345
• 全文大小：806 K

文摘

Interleukin (IL)-4 is a critical stimulator that induces 蓻 germline transcripts (蓻GT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL-4-induced 蓻GT expression. PGG exerted its inhibitory function by suppressing IL-4-induced activation of IL-4R伪, JAK3 and STAT6. Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin-induced IgE production in vivo by inhibiting IL-4-induced 蓻GT expression and the IL-4 signaling pathway. In conclusion, our results suggest that tannic acid may attenuate allergic diseases by suppressing IgE production by inhibiting IL-4-induced signaling.