A novel C-type lectin with triple carbohydrate recognition domains has critical roles for the hard tick Haemaphysalis longicornis against Gram-negative bacteria
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- 作者：Hiroki Maedaa ; b ; Takeshi Miyatac ; Kodai Kusakisakoa ; b ; Remil Linggatong Galayd ; Melbourne Rio Talactaca ; b ; Rika Umemiya-Shirafujie ; Masami Mochizukia ; b ; Kozo Fujisakif ; Tetsuya Tanakaa ; b ; tetsuya@ms.kagoshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tick ; C-type lectin ; Innate immunity ; Recombinant ; Gram-negative bacteria
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：38-47
- 全文大小：2635 K
文摘
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HlCLec with triple CRDs was identified from Haemaphysalis longicornis.
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HlCLec mRNA is upregulated during blood feeding and highest in the midgut and ovary.
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Each CRD showed binding ability to both Escherichia coli and S. aureus.
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Each CRD had no growth inhibitory effeect to both E. coli and S. aureus.
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E. coli injection after HlCLec silencing caused significant decrease in tick survival.