One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates

详细信息    查看全文

• 作者：Hiromichi Fujioka ; Kenichi Murai ; Ozora Kubo ; Yusuke Ohba ; Yasuyuki Kita
• 关键词：Imidazoline ; Aldehyde ; Diamine ; NBS
• 刊名：Tetrahedron
• 出版年：2007
• 出版时间：15 January 2007
• 年：2007
• 卷：63
• 期：3
• 页码：638-643
• 全文大小：466 K

文摘

Imidazolines were prepared in one-pot operation from aldehydes and diamines through oxidation of aminal intermediates by NBS. This method could be applied to various aromatic and aliphatic aldehydes and N-nonsubstituted and N-monosubstituted 1,2-diamines. Furthermore, it was found that CH₂Cl₂ could be altered to TBME, a more environmentally friendly solvent, in the reaction using N-nonsubstituted 1,2-diamines. The reaction conditions were very mild and chemoselective.