A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy
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- 作者：Miki Ando1 ; Toshinobu Nishimura1 ; 11 ; Satoshi Yamazaki1 ; Tomoyuki Yamaguchi1 ; Ai Kawana-Tachikawa2 ; 10 ; Tomonari Hayama1 ; Yusuke Nakauchi1 ; Jun Ando5 ; Yasunori Ota3 ; Satoshi Takahashi4 ; Ken Nishimura6 ; Manami Ohtaka7 ; Mahito Nakanishi7 ; John J. Miles8 ; Scott R. Burrows8 ; Malcolm K. Brenner9 ; Hiromitsu Nakauchi1 ; 11 ; nakauchi@ims.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：13 October 2015
- 年：2015
- 卷：5
- 期：4
- 页码：597-608
- 全文大小：2782 K
文摘
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iPSC-derived rejuvenated CTLs are effective against EBV-induced tumors in vivo
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Rejuvenated CTLs are implemented with an inducible caspase-9 (iC9)-based suicide system
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Upon induction, the iC9 system efficiently leads to apoptosis in rejuvenated CTLs
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The iC9-based system provides a safeguard for future iPSC-mediated cell therapy