Studies on the α-(1→4)- and α-(1→8)-fucosylation of sialic acid for the total assembly of the glycan portions of complex HPG-series gangliosides

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• 作者：Hiromune Ando ; Hiroyo Shimizu ; Yukari Katano ; Yusuke Koike ; Sachiko Koizumi ; Hideharu Ishida and Makoto Kiso
• 关键词：Fucosylation ; 1 ; 5-Lactamized sialyl acceptor ; Ganglioside HPG-1 ; Ganglioside HPG-7
• 刊名：Carbohydrate Research
• 出版年：2006
• 出版时间：24 July 2006
• 年：2006
• 卷：341
• 期：10
• 页码：1522-1532
• 全文大小：220 K

文摘

A synthetic study on α-(1→4) and α-(1→8)-fucosylation of sialic acid is reported, with the ultimate aim being the total assembly of the glycan portion of HPG-series gangliosides. In both types of fucosylations, the combination of a phenylthio fucosyl donor and a 1,5-lactamized acceptor provided high-yielding glycosylations to afford α-fucosyl-sialic acid sequences. The obtained α-Fucp-(1→8)-NeupNAc glycan having a 1,5-lactam bridge has been successfully transformed into the corresponding glycosyl donor.